Breast cancer in young women: Clinicopathological features and biological specificity

  • Sidoni A
  • Cavaliere A
  • Bellezza G
 et al. 
  • 0

    Readers

    Mendeley users who have this article in their library.
  • 90

    Citations

    Citations of this article.

Abstract

Literature data suggest that breast cancers occurring in young patients may be different from those arising in older women. In this study the clinicopathologic characteristics of 50 patients under 40 years of age were compared with those of patients aged over 60. Patients under 40 years old more frequently had a family history of breast cancer than did older patients (24% vs 17%) and had more often used oral contraceptives (29% vs 13%); on average they had experienced menarche 1 year earlier. For early onset breast carcinomas there was a higher frequency of grade 3 tumours (38% vs 17%) and oestrogen receptor negativity (46% vs 20%). In addition, in younger patients the carcinomas were mostly DNA aneuploid (78% vs 58%), with a higher proliferation rate (48% vs 26%) and more frequent c-erbB-2 overexpression (48% vs 26%) and p53 alteration (30% vs 8%). Our data demonstrate that breast cancers arising in young women have a significantly different biopathological profile from those in older patients, with a predominance of unfavourable prognostic parameters. © 2003 Elsevier Science Ltd. All rights reserved.

Author-supplied keywords

  • Breast cancer
  • Prognostic factors
  • Young women

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Angelo Sidoni

  • A. Cavaliere

  • G. Bellezza

  • M. Scheibel

  • E. Bucciarelli

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free