The first total synthesis of the alkaloid fumaramidine is reported. The synthetic tactics involve the sequential construction of the isoindolinone template by a Parham cyclization process followed by benzylic lactam deprotonation, interception with the suitable carboxaldehyde and ultimate E1cb elimination. Final N-lactam deprotection completes the synthesis of the Z configured title compound. © 2006 Elsevier Ltd. All rights reserved.
CITATION STYLE
Lamblin, M., Couture, A., Deniau, E., & Grandclaudon, P. (2006). A brief total synthesis of fumaramidine. Tetrahedron, 62(12), 2917–2921. https://doi.org/10.1016/j.tet.2006.01.008
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