Both prophylactic and therapeutic vaccines targeting a wide variety of cancers are being developed. Because of the potency of cell-mediated immunity, many vaccine strategies are focused on activating tumor-specific cytotoxic CD8+ T lymphocytes. CD4+ T lymphocytes are a key element in optimal activation of CD8+ T cells and in the maintenance of immune memory, and therefore their activation is critical for cancer vaccine efficacy. This article reviews the mechanisms by which CD4+ T cells facilitate tumor immunity and the vaccine strategies that enhance CD4 + T cell activity. Copyright © Taylor & Francis Inc.
CITATION STYLE
Ostrand-Rosenberg, S. (2005). CD4+ T lymphocytes: A critical component of antitumor immunity. Cancer Investigation. https://doi.org/10.1081/CNV-67428
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