C-erbB2 oncoprotein: prognostic marker in breast cancer.

  • Rosian A
  • Lazar E
  • Dema A
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Abstract

AIM: The invasive mammary cancer is the most frequent malign tumor of a woman. Among the potential prognostic factors are included the biomarkers which measure or are associated with biological processes involved in the tumoral progression. We study the prognostic importance of the c-erbB2 oncoprotein in the invasive mammary cancer. MATERIAL AND METHODS: We included in the study 56 female patients suffering of invasive mammary cancer. The tissue fragments were fitted in formol, included to paraffin, commonly colored haematoxylin-eosine (HE); for the determination of the c-erbB2 we used the immunohistochemical method of avidin-biotin (ABC) complex. RESULTS: From the total of 56 tumors, 38 (67.9%) presented different degrees of positivity; 18 (32.1%) did not express the oncoprotein c-erbB2. CONCLUSIONS: The positivity of c-erbB2 oncoprotein was correlated with the size of the tumor; the carcinomas which are not infiltrative ductal, knows as having a better prognostic, were c-erbB2 negative.

Author-supplied keywords

  • immunohistochemistry
  • mammary cancer
  • oncoprotein c-erbb2

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Authors

  • Anca Rosian

  • Elena Lazar

  • Alice Dema

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