C-erbB2 oncoprotein: prognostic marker in breast cancer.

  • Rosian A
  • Lazar E
  • Dema A
  • 1


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


AIM: The invasive mammary cancer is the most frequent malign tumor of a woman. Among the potential prognostic factors are included the biomarkers which measure or are associated with biological processes involved in the tumoral progression. We study the prognostic importance of the c-erbB2 oncoprotein in the invasive mammary cancer. MATERIAL AND METHODS: We included in the study 56 female patients suffering of invasive mammary cancer. The tissue fragments were fitted in formol, included to paraffin, commonly colored haematoxylin-eosine (HE); for the determination of the c-erbB2 we used the immunohistochemical method of avidin-biotin (ABC) complex. RESULTS: From the total of 56 tumors, 38 (67.9%) presented different degrees of positivity; 18 (32.1%) did not express the oncoprotein c-erbB2. CONCLUSIONS: The positivity of c-erbB2 oncoprotein was correlated with the size of the tumor; the carcinomas which are not infiltrative ductal, knows as having a better prognostic, were c-erbB2 negative.

Author-supplied keywords

  • immunohistochemistry
  • mammary cancer
  • oncoprotein c-erbb2

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Anca Rosian

  • Elena Lazar

  • Alice Dema

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free