Cerebral blood flow in temporal lobe epilepsy: A partial volume correction study

  • Giovacchini G
  • Bonwetsch R
  • Herscovitch P
 et al. 
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Abstract

Purpose: Previous studies in temporal lobe epilepsy (TLE) have shown that, owing to brain atrophy, positron emission tomography (PET) can overestimate deficits in measures of cerebral function such as glucose metabolism (CMR glu) and neuroreceptor binding. The magnitude of this effect on cerebral blood flow (CBF) is unexplored. The aim of this study was to assess CBF deficits in TLE before and after magnetic resonance imaging-based partial volume correction (PVC). Methods: Absolute values of CBF for 21 TLE patients and nine controls were computed before and after PVC. In TLE patients, quantitative CMRglu measurements also were obtained. Results: Before PVC, regional values of CBF were significantly (p

Author-supplied keywords

  • *brain blood flow
  • *temporal lobe epilepsy
  • adult
  • algorithm
  • amygdaloid nucleus
  • article
  • brain atrophy/di [Diagnosis]
  • brain function
  • brain ischemia
  • brain region
  • brain size
  • clinical article
  • controlled study
  • disease duration
  • epileptic focus
  • female
  • fluorodeoxyglucose f 18
  • glucose metabolism
  • hippocampus
  • human
  • insula
  • male
  • nuclear magnetic resonance imaging
  • positron emission tomography
  • quantitative analysis
  • receptor binding
  • spindle cell
  • statistical significance
  • temporal cortex

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Authors

  • G Giovacchini

  • R Bonwetsch

  • P Herscovitch

  • R E Carson

  • W H Theodore

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