Chromosomes and speciation in Mus musculus domesticus

  • Capanna E
  • Castiglia R
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Thirty years after its identification, the model of chromosomal speciation in Mus musculus domesticus is reeval-uated using the methods of population biology, molecular cyto-genetics and functional genomics. Three main points are con-sidered: (1) the structural predisposition of M. m. domesticus chromosomes to Robertsonian fusion; (2) the impediment of structural heterozygosity to gene flow between populations of mice with karyotypes rearranged by Robertsonian fusion and between them and populations with the standard all-acrocent-ric 40-chromosome karyotype; (3) the selective advantage of chromosomal novelty, essential for the attainment of homozy-gosis and the rapid fixation of the new karyotype in the popula-tion.

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  • E. Capanna

  • R. Castiglia

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