Circadian rhythms: From basic mechanisms to the intensive care unit

  • Chan M
  • Spieth P
  • Quinn K
 et al. 
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Abstract

OBJECTIVE:: Circadian rhythms are intrinsic timekeeping mechanisms that allow for adaptation to cyclic environmental changes. Increasing evidence suggests that circadian rhythms may influence progression of a variety of diseases as well as effectiveness and toxicity of drugs commonly used in the intensive care unit. In this perspective, we provide a brief review of the molecular mechanisms of circadian rhythms and its relevance to critical care. DATA SOURCES, STUDY SELECTION, DATA EXTRACTION, AND DATA SYNTHESIS:: Articles related to circadian rhythms and organ systems in normal and disease conditions were searched through the PubMed library with the goal of providing a concise review. CONCLUSIONS:: Critically ill patients may be highly vulnerable to disruption of circadian rhythms as a result of the severity of their underlying diseases as well as the intensive care unit environment where noise and frequent therapeutic/diagnostic interventions take place. Further basic and clinical research addressing the importance of circadian rhythms in the context of critical care is warranted to develop a better understanding of the complex pathophysiology of critically ill patients as well as to identify novel therapeutic approaches for these patients

Author-supplied keywords

  • Basic
  • Circadian
  • Circadian rhythm
  • Clinical
  • Complex
  • Data
  • Disease
  • Disruption
  • Drug
  • Environment
  • Environmental
  • Extraction
  • Libraries
  • Library
  • Mechanism
  • Molecular
  • Research
  • Review
  • Rhythm
  • Selection
  • Synthesis
  • System
  • Therapeutic
  • Toxicity

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Authors

  • M C Chan

  • P M Spieth

  • K Quinn

  • M Parotto

  • H Zhang

  • A S Slutsky

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