Circumdatin G, a new alkaloid from the fungus Aspergillus ochraceus

  • Dai J
  • Carté B
  • Sidebottom P
 et al. 
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Abstract

The crude ext. of the broth of Aspergillus ochraceus was found to inhibit the final stage of polyprotein processing during hepatitis C virus replication. Bioassay-guided fractionation led to the isolation of the known compd. mellein as the active component of the ext. Also isolated were circumdatin F and a new alkaloid, circumdatin G (I). The structure of I was detd. by spectroscopic anal. [on SciFinder(R)]

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Authors

  • Jin Rui Dai

  • Brad K. Carté

  • Philip J. Sidebottom

  • Alex Lee Sek Yew

  • Yicun Huang

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