(Chemical Equation Presented) A series of C-linked antifreeze glycoprotein analogues have been prepared to evaluate antifreeze activity as a function of distance between the carbohydrate moiety and polypeptide backbone. The building blocks for these analogues were prepared using either an olefin cross-metathesis or catalytic asymmetric hydrogenation. Analysis of antifreeze protein-specific activity revealed that only analogue 2a (n = 1) was a potent recrystallization inhibitor and thus has potential medical and industrial applications. © 2005 American Chemical Society.
CITATION STYLE
Liu, S., & Ben, R. N. (2005). C-linked galactosyl serine AFGP analogues as potent recrystallization inhibitors. Organic Letters, 7(12), 2385–2388. https://doi.org/10.1021/ol050677x
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