C-linked galactosyl serine AFGP analogues as potent recrystallization inhibitors

  • Liu S
  • Ben R
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Abstract

[reaction: see text] A series of C-linked antifreeze glycoprotein analogues have been prepared to evaluate antifreeze activity as a function of distance between the carbohydrate moiety and polypeptide backbone. The building blocks for these analogues were prepared using either an olefin cross-metathesis or catalytic asymmetric hydrogenation. Analysis of antifreeze protein-specific activity revealed that only analogue 2a (n = 1) was a potent recrystallization inhibitor and thus has potential medical and industrial applications.

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Authors

  • Suhuai Liu

  • Robert N. Ben

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