Use of coherent control methods through scattering biological tissue to achieve functional imaging

  • Dela Cruz J
  • Pastirk I
  • Comstock M
 et al. 
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We test whether coherent control methods based on ultrashort-pulse phase shaping can be applied when the laser light propagates through biological tissue. Our results demonstrate experimentally that the spectral-phase properties of shaped laser pulses optimized to achieve selective two-photon excitation survive as the laser pulses propagate through tissue. This observation is used to obtain functional images based on selective two-photon excitation of a pH-sensitive chromophore in a sample that is placed behind a slice of biological tissue. Our observation of coherent control through scattering tissue suggests possibilities in multiphoton-based imaging and photodynamic therapy.

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  • Johanna M Dela Cruz

  • Igor Pastirk

  • Matthew Comstock

  • Vadim V Lozovoy

  • Marcos Dantus

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