The first cobalt-catalyzed cyanation, halogenation, and allylation via C-H activation have been realized. These formal SN-type reactions generate valuable (hetero)aryl/alkenyl nitriles, iodides, and bromides as well as allylated indoles using a bench-stable Co(III) catalyst. High regio- and mono-selectivity were achieved for these reactions. Additionally, allylation proceeded efficiently with a turnover number of 2200 at room temperature, which is unprecedented for this Co(III) catalyst. Alkenyl substrates and amides have been successfully utilized in Cp∗Co(III)-catalyzed C-H activation for the first time.
CITATION STYLE
Yu, D. G., Gensch, T., De Azambuja, F., Vásquez-Céspedes, S., & Glorius, F. (2014). Co(III)-catalyzed C-H activation/formal SN-type reactions: Selective and efficient cyanation, halogenation, and allylation. Journal of the American Chemical Society, 136(51), 17722–17725. https://doi.org/10.1021/ja511011m
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