Here, we describe the first identification of colistin-heteroresistant Enterobacter cloacae in the United States. Treatment of this isolate with colistin increased the frequency of the resistant subpopulation and induced cross-resistance to the host antimicrobial lysozyme. This is the first description ofheteroresistance conferring cross-resistance to a host antimicrobial and suggests that clinical treatment with colistin may inadvertently select for bacteria that are resistant to components of the host innate immune system. Copyright © 2014 American Society for Microbiology. All Rights Reserved.
CITATION STYLE
Napier, B. A., Band, V., Burd, E. M., & Weiss, D. S. (2014). Colistin heteroresistance in Enterobacter cloacae is associated with cross-resistance to the host antimicrobial lysozyme. Antimicrobial Agents and Chemotherapy, 58(9), 5594–5597. https://doi.org/10.1128/AAC.02432-14
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