Comparative effects of permanent biventricular and right-univentricular pacing in heart failure patients with chronic atrial fibrillation

  • Leclercq C
  • 13


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


Background: One third of chronic heart failure patients have major intraventricular conduction and uncoordinated ventricular contraction. Non-controlled studies suggest that biventricular pacing may improve haemodynamics and well-being by reducing ventricular asynchrony. The aim of this trial was to assess the clinical efficacy and safety of this new therapy in patients with chronic atrial fibrillation. Methods: Fifty nine NYHA class III patients with left ventricular systolic dysfunction, chronic atrial fibrillation, slow ventricular rate necessitating permanent ventricular pacing, and a wide QRS complex (paced width ≥200 ms), were implanted with transvenous biventricular-VVIR pacemakers. This single-blind, randomized, controlled, cross-over study compared the patients' parameters, as monitored during two 3-month treatment periods of conventional right-univentricular vs biventricular pacing. The primary end-point was the 6-min walked distance, secondary endpoints were peak oxygen uptake, quality-of-life, hospitalizations, patients' preferred study period and mortality. Results: Because of a higher than expected drop-out rate (42%), only 37 patients completed both crossover phases. In the intention-to-treat analysis, we did not observe a significant difference. However, in the patients with effective therapy the mean walked distance increased by 9·3% with biventricular pacing (374 ± 108 vs 342 ± 103 m in univentricular; P=0·05). Peak oxygen uptake increased by 13% (P=0·04). Hospitalizations decreased by 70% and 85% of the patients preferred the biventricular pacing period (Pe

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • C Leclercq

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free