This paper presents a method for classification of structural brain magnetic resonance (MR) images, by using a combination of deformation-based morphometry and machine learning methods. A morphological representation of the anatomy of interest is first obtained using a high-dimensional mass-pre- serving template warping method, which results in tissue density maps that constitute local tissue volumetric measurements. Re- gions that display strong correlations between tissue volume and classification (clinical) variables are extracted using a watershed segmentation algorithm, taking into account the regional smooth- ness of the correlation mapwhich is estimated by a cross-validation strategy to achieve robustness to outliers. A volume increment algorithm is then applied to these regions to extract regional volumetric features, from which a feature selection technique using support vector machine (SVM)-based criteria is used to select the most discriminative features, according to their effect on the upper bound of the leave-one-out generalization error. Finally, SVM-based classification is applied using the best set of features, and it is tested using a leave-one-out cross-validation strategy. The results onMRbrain images of healthy controls and schizophrenia patients demonstrate not only high classification accuracy (91.8% for female subjects and 90.8% for male subjects), but also good stability with respect to the number of features selected and the size of SVM kernel used.
Mendeley saves you time finding and organizing research
Choose a citation style from the tabs below