To compare the relapse rate of artesunate with tetracycline and quinine with tetracycline in uncomplicated falciparum malaria

  • Taj A
  • Sharif M
  • Mahmood A
 et al. 
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Abstract

Objective: To determine the relapse rate of falciparum malaria treated with artesunate plus tetracycline (AT) versus quinine plus tetracycline (QT) in uncomplicated patients of malaria. Methodology: Across sectional comparative study was carried out at Combined Military Hospital, Quetta from 01 May to 30 November 2006. Ninety patients of age-sex matched group with uncomplicated falciparum malaria having parasitemia {>}1{%}, age between 14-65 yrs, either sex and with no previous malaria treatment related to the present attack were recruited from emergency department, medical wards, included in the study. One group was given quinine along with tetracycline (QT) and the other group was given artemesinin and tetracycline (AT). The patient was discharged from the hospital when three negative blood smears were obtained. Thereafter, blood smears were taken at days 7, 14, 21 {&} 28 after the start of the treatment, as outdoor patients. Parasitological response was regarded as radical cure with parasite clearance by day 7 without recrudescence up to day 28. Fever and parasite clearance times were noted as the time from the initiation of treatment to the first of three consecutive normal axillary temperature readings ({

Author-supplied keywords

  • Artesunate
  • Drug resistance
  • Malaria
  • Plasmodium falciparum
  • Quinine

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  • ISBN: 1682-024X
  • ISSN: 1682024X
  • SCOPUS: 2-s2.0-66549083722
  • PUI: 354685684
  • PMID: 20093175191
  • SGR: 66549083722

Authors

  • Ali Taj

  • Muhammad Ashraf Sharif

  • Asad Mahmood

  • Muhammad Luqman

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