The complete genome sequence of Propionibacterium acnes, a commensal of human skin

  • Bruggemann H
  • Henne A
  • Hoster F
 et al. 
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Abstract

Propionibacterium acnes is a major inhabitant of adult human skin, where it resides within sebaceous follicles, usually as a harmless commensal although it has been implicated in acne vulgaris formation. The entire genome sequence of this Gram-positive bacterium encodes 2333 putative genes and revealed numerous gene products involved in degrading host molecules, including sialidases, neuraminidases, endoglycoceramidases, lipases, and pore-forming factors. Surface-associated and other immunogenic factors have been identified, which might be involved in triggering acne inflammation and other P. acnes-associated diseases

Author-supplied keywords

  • A
  • Acne Vulgaris
  • Adult
  • Amino Acid Motifs
  • Antigens
  • BACTERIUM
  • Bacteria
  • Base Sequence
  • Computational Biology
  • DISEASE
  • Esterases
  • GENE
  • Genes
  • Genetics
  • Heat Shock
  • Heat Shock Protein
  • Humans
  • Hydrolases
  • Inflammation
  • Laboratories
  • Lipase
  • Molecular Sequence Data
  • Oxidative Phosphorylation
  • PROTEIN
  • Propionibacterium acnes
  • Proteins
  • Skin
  • amino acid sequence
  • antigens,bacterial
  • bacterial
  • bacterial proteins
  • chemistry
  • chromosomes,bacterial
  • complete genome
  • energy metabolism
  • genes,bacterial
  • genome
  • genome sequence
  • genome,bacterial
  • genomics
  • gram-positive
  • gram-positive bacteria
  • heat shock proteins
  • heat-shock
  • heat-shock proteins
  • human
  • immunology
  • metabolism
  • microbiology
  • physiology
  • research
  • sequence
  • sequence analysis,dna

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Authors

  • H Bruggemann

  • a Henne

  • F Hoster

  • H Liesegang

  • a Wiezer

  • a Strittmatter

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