The Complete Genome Sequence of Propionibacterium Acnes, a Commensal of Human Skin

  • Brüggemann H
  • Henne A
  • Hoster F
 et al. 
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Propionibacterium acnes is a major inhabitant of adult human skin, where it resides within sebaceous follicles, usually as a harmless commensal although it has been implicated in acne vulgaris formation. The entire genome sequence of this Gram-positive bacterium encodes 2333 putative genes and revealed numerous gene products involved in degrading host molecules, including sialidases, neuraminidases, endoglycoceramidases, lipases, and pore-forming factors. Surface-associated and other immunogenic factors have been identified, which might be involved in triggering acne inflammation and other P. acnes-associated diseases.

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  • H. Brüggemann

  • A Henne

  • F Hoster

  • H Liesegang

  • A Wiezer

  • A Strittmatter

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