A complex flow pattern of low shear stress and flow reversal promotes monocyte binding to endothelial cells

  • Honda H
  • Hsiai T
  • Wortham C
 et al. 
  • 18

    Readers

    Mendeley users who have this article in their library.
  • 48

    Citations

    Citations of this article.

Abstract

Predilection sites for atherosclerosis within the vasculature are characterized by low shear stress and flow reversal. In this study, endothelial cells were exposed to a complex flow pattern that was characterized by particle velocity determination. Bovine aortic endothelial cells exposed to low shear stress and flow reversal demonstrated higher levels of monocyte binding compared to endothelial cells exposed to one-directional flow. In addition, endothelial cells exposed to low shear stress and flow reversal responded to inflammatory stimuli with substantial increases in monocyte binding, similar to that seen in cells exposed to one-directional flow. These findings suggest a mechanism by which areas of low shear stress and flow reversal are predisposed to the development of atherosclerotic lesions. © 2001 Elsevier Science Ireland Ltd. All rights reserved.

Author-supplied keywords

  • Atherosclerosis
  • Endothelial cells
  • Flow reversal
  • Monocyte binding
  • Shear stress

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Get full text

Authors

  • Henry M. Honda

  • Tzung Hsiai

  • Charles M. Wortham

  • Mingdar Chen

  • Hank Lin

  • Mohamad Navab

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free