Correlation of clinical and immunological data in a metastatic melanoma patient with heterogeneous tumor responses to ipilimumab therapy

  • Yuan J
  • Page D
  • Ku G
 et al. 
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Melanoma patients treated with anti-CTLA-4 have shown a range of anti-tumor responses. In this report, we describe the response of a single patient to anti-CTLA-4, with individual lesions disappearing, others stabilizing, and others progressing. These responses can be viewed as a clear manifestation of cancer immunoediting and its three phases of elimination, equilibrium and escape, with each tumor in this patient being at a discrete stage in the process. The patient's course and associated immunological monitoring and other laboratory data are presented in an immunogram, a way to visualize temporal associations between the multiple clinical and laboratory parameters.

Author-supplied keywords

  • Case report
  • Human
  • Immunoediting
  • Immunogram
  • Ipilimumab
  • Melanoma

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  • SGR: 76149137243
  • PUI: 358252084
  • SCOPUS: 2-s2.0-76149137243
  • ISBN: 1424-9634
  • ISSN: 14249634
  • PMID: 20052966


  • Jianda Yuan

  • David B. Page

  • Geoffrey Y. Ku

  • Yanyun Li

  • Zhenyu Mu

  • Charlotte Ariyan

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