Cotransplantation of haploidentical mesenchymal stem cells to enhance engraftment of hematopoietic stem cells and to reduce the risk of graft failure in two children with severe aplastic anemia.

  • Fang B
  • Li J
  • Song Y
 et al. 
  • 1

    Readers

    Mendeley users who have this article in their library.
  • N/A

    Citations

    Citations of this article.

Abstract

MSC have been suggested to be the precursor cells in the bone marrow stroma that provide a scaffold and promote hematopoiesis. They have therefore been suggested to enhance engraftment after autologous and allogeneic HSC transplantation. In patients undergoing transplantation, MSC infusion was shown to be safe and to enhance engraftment of HSC, as well as to reduce the incidence of both acute and chronic GVHD. We cotransplanted haploidentical AMSC with HLA-identical sibling-matched PBSC in two pediatric patients with refractory SAA after primary or secondary graft failure. At present, the two patients are more than two yr after cotransplantation without any treatment, transfusion-independent and in good condition. Thus, cotransplantation of MSC might enhance engraftment of HSC in patients regrafted for graft failure.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

There are no full text links

Authors

  • Baijun Fang

  • Jing Li

  • Yongping Song

  • Robert Chunhua Zhao

  • Yuanfang Ma

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free