Continued interest in cytotoxic alkaloids resulted in the isolation of 37 alkaloids including 29 known monoterpenoid indole alkaloids from the aerial parts of Tabernaemontana officinalis. Of the remaining 8 alkaloids, six were bisindole alkaloids named taberdivarines A-F (1-6) and the two were monomers named taberdivarines G and H (7-8). Alkaloids 1 and 2 are voaphylline-vobasinyl type bisindole alkaloids, a structural type previously unknown, while 3-6 exhibited cytotoxicity against three human cancer cell lines HeLa, MCF-7, and SW480 with IC50 values ranging from 1.42 to 11.35 μM.
CITATION STYLE
Zhang, B. J., Teng, X. F., Bao, M. F., Zhong, X. H., Ni, L., & Cai, X. H. (2015). Cytotoxic indole alkaloids from Tabernaemontana officinalis. Phytochemistry, 120, 46–52. https://doi.org/10.1016/j.phytochem.2014.12.025
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