Cytotoxic xanthone-anthraquinone heterodimers from an unidentified fungus of the order Hypocreales (MSX 17022)

  • Ayers S
  • Graf T
  • Adcock A
 et al. 
  • 6


    Mendeley users who have this article in their library.
  • 18


    Citations of this article.


Two new xanthone-anthraquinone heterodimers, acremoxanthone C (5) and acremoxanthone D (2), have been isolated from an extract of an unidentified fungus of the order Hypocreales (MSX 17022) by bioactivity-directed fractionation as part of a search for anticancer leads from filamentous fungi. Two known related compounds, acremonidin A (4) and acremonidin C (3) were also isolated, as was a known benzophenone, moniliphenone (1). The structures of these isolates were determined via extensive use of spectroscopic and spectrometric tools in conjunction with comparisons to the literature. All compounds (1-5) were evaluated against a suite of biological assays, including those for cytotoxicity, inhibition of the 20S proteasome, mitochondrial transmembrane potential and nuclear factor-κB.

Author-supplied keywords

  • 20S proteasome
  • acremonidin
  • anthraquinone
  • cytotoxicity
  • fungus
  • moniliphenone
  • xanthone

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Get full text


  • Sloan Ayers

  • Tyler N. Graf

  • Audrey F. Adcock

  • David J. Kroll

  • Qi Shen

  • Steven M. Swanson

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free