Dendritic cells signal T cells in the absence of exogenous antigen

  • Kondo T
  • Cortese I
  • Markovic-Plese S
 et al. 
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Abstract

Interactions with self-major histocompatibility complex molecules on dendritic cells (DCs) are important for the survival of mature CD4+ T cells. We have followed the DC-mediated signal from the T cell surface to the nucleus and identified a pattern of activation that correlates with increased in vitro survival. This response is induced exclusively by DCs and is likely associated with a modulation of the T cell activation threshold. We have also found that DC-mediated activation results in antigen-independent cytokine gene expression, which points to a new role for DCs in shaping the cytokine milieu. Such antigen-independent activation of T cells may play a role in protective immunity, but may also induce and perpetuate autoimmune states such as multiple sclerosis.

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Authors

  • Takayuki Kondo

  • Irene Cortese

  • Silva Markovic-Plese

  • Klaus Peter Wandinger

  • Charles Carter

  • Martin Brown

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