Eight new dihydro-β-agarofurans, denhaminols A-H (1-8), were isolated from the leaves of the Australian rainforest tree Denhamia celastroides. The chemical structures of 1-8 were elucidated following analysis of 1D/2D NMR and MS data. The absolute configuration of denhaminol A (1) was determined by single-crystal X-ray crystallography. All compounds were evaluated for cytotoxic activity against the human prostate cancer cell line LNCaP, using live-cell imaging and metabolic assays. Denhaminols A (1) and G (7) were also tested for their effects on the lipid content of LNCaP cells. This is the first report of secondary metabolites from D. celastroides.
CITATION STYLE
Levrier, C., Sadowski, M. C., Nelson, C. C., Healy, P. C., & Davis, R. A. (2015). Denhaminols A-H, Dihydro-β-agarofurans from the Endemic Australian Rainforest Plant Denhamia celastroides. Journal of Natural Products, 78(1), 111–119. https://doi.org/10.1021/np500740f
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