Detecting fungal pathogens

  • Dostert C
  • Tschopp J
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Fungal infection is 'sensed' by host cell–expressed receptors. Two papers demonstrate that the C-type lectin receptor dectin-1 is required in vivo for cytokine production and killing of different fungal pathogens. -------------------------------------------------------------------------------- Innate immune responses are mediated by phagocytic cells such as macrophages and neutrophils, which ingest and kill invading pathogens and then trigger the adaptive immune system through the secretion of cytokines and chemokines. Host recognition of invading microorganisms relies on evolutionarily ancient, germline-encoded pattern-recognition receptors (PRRs), which recognize highly conserved invariable molecular patterns often essential for survival of microorganisms.

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  • Catherine Dostert

  • Jürg Tschopp

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