Cellular metabolism is affected by many factors in a cell's environment. Given a sufficiently sensitive method for measuring cellular metabolic rates, it should be possible to detect a wide variety of chemical and physical stimuli. A biosensor has been constructed in which living cells are confined to a flow chamber in which a potentiometric sensor continually measures the rate of production of acidic metabolites. Exploratory studies demonstrate several applications ofthe device in basic science and technology.
CITATION STYLE
Parce, J. W., Owicki, J. C., Kercso, K. M., Sigal, G. B., Wada, H. G., Muir, V. C., … McConnell, H. M. (1989). Detection of cell-affecting agents with a silicon biosensor. Science, 246(4927), 243–247. https://doi.org/10.1126/science.2799384
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