Development of layer 1 neurons in the mouse neocortex.

  • Ma J
  • Yao X
  • Fu Y
 et al. 
  • 7


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


Layer 1 of the neocortex harbors a unique group of neurons that play crucial roles in synaptic integration and information processing. Although extensive studies have characterized the properties of layer 1 neurons in the mature neocortex, it remains unclear how these neurons progressively acquire their distinct morphological, neurochemical, and physiological traits. In this study, we systematically examined the dynamic development of Cajal-Retzius cells and γ-aminobutyric acid (GABA)-ergic interneurons in layer 1 during the first 2 postnatal weeks. Cajal-Retzius cells underwent morphological degeneration after birth and gradually disappeared from layer 1. The majority of GABAergic interneurons showed clear expression of at least 1 of the 6 distinct neurochemical markers, including Reelin, GABA-A receptor subunit delta (GABAARδ), neuropeptide Y, vasoactive intestinal peptide (VIP), calretinin, and somatostatin from postnatal day 8. Furthermore, according to firing pattern, layer 1 interneurons can be divided into 2 groups: late-spiking (LS) and burst-spiking (BS) neurons. LS neurons preferentially expressed GABAARδ, whereas BS neurons preferentially expressed VIP. Interestingly, both LS and BS neurons exhibited a rapid electrophysiological and morphological development during the first postnatal week. Our results provide new insights into the molecular, morphological, and functional developments of the neurons in layer 1 of the neocortex.

Author-supplied keywords

  • Action Potentials
  • Animals
  • Calbindin 2
  • Calbindin 2: analysis
  • Cell Adhesion Molecules
  • Cell Count
  • Extracellular Matrix Proteins
  • Extracellular Matrix Proteins: analysis
  • GABA-A
  • GABA-A: analysis
  • GABAergic Neurons
  • GABAergic Neurons: cytology
  • GABAergic Neurons: metabolism
  • GABAergic Neurons: physiology
  • Interneurons
  • Interneurons: cytology
  • Interneurons: metabolism
  • Interneurons: physiology
  • Mice
  • Neocortex
  • Neocortex: cytology
  • Neocortex: growth & development
  • Nerve Tissue Proteins
  • Nerve Tissue Proteins: analysis
  • Neuronal
  • Neuronal: analysis
  • Neurons
  • Neurons: cytology
  • Neurons: metabolism
  • Neurons: physiology
  • Neuropeptide Y
  • Neuropeptide Y: analysis
  • Receptors
  • Serine Endopeptidases
  • Serine Endopeptidases: analysis
  • Somatostatin
  • Somatostatin: analysis
  • Transgenic
  • Vasoactive Intestinal Peptide
  • Vasoactive Intestinal Peptide: analysis

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Jian Ma

  • Xing-Hua Yao

  • Yinghui Fu

  • Yong-Chun Yu

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free