The use of different sugars as fine and coarse carriers for aerosolised salbutamol sulphate

  • Tee S
  • Marriott C
  • Zeng X
 et al. 
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Abstract

The aim of this study was to investigate the dispersion and deaggregation of a model drug, salbutamol sulphate (SS), using lactose, mannitol or sorbitol as coarse and fine carriers. Binary and tertiary formulations containing micronised salbutamol sulphate (SS) and sieved (63-90 μm) coarse sugar crystals or salbutamol sulphate (SS) with a mixture of coarse and fine sugar particles were prepared. Factorial design was employed to investigate the effects of three variables, i.e. the chemical entity of the coarse sugar carrier, the chemical entity of the fine sugar and the concentration of fine sugar, on the dispersion and deaggregation of salbutamol sulphate after aerosolisation at 60 l/min via a Rotahaler® into a twin stage liquid impinger (TSI). The binary formulations containing the different sugar entities produced differences in the fine (< 6.4 μm) particle fraction (FPF) of SS in a decreasing order of mannitol > sorbitol > lactose, but failed to produce efficient dispersion of SS since the FPF was

Author-supplied keywords

  • Dry powder inhalers
  • Lactose
  • Mannitol
  • Salbutamol sulphate
  • Sorbitol

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Authors

  • S. K. Tee

  • C. Marriott

  • X. M. Zeng

  • G. P. Martin

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