Differential roles for the inositol phosphatase SHIP in the regulation of macrophages and lymphocytes

  • Leung W
  • Tarasenko T
  • Bolland S
  • 29


    Mendeley users who have this article in their library.
  • 37


    Citations of this article.


The SH2 domain-containing inositol 5'-phosphatase (SHIP) negatively regulates antigen, cytokine, and Fc receptor signaling pathways in immune cells. Our knowledge of the function of SHIP largely derives from in vitro studies that utilized SHIP-deficient cell lines and immune cells isolated from SHIP null mice. To avoid the pleiotropic effects observed in mice with germline deletion of SHIP, we have used the Cre-lox system to generate SHIP conditional knockout mice with deletion in specific immune cell populations. In this review we summarize our observations from mice with deletion of SHIP in lymphocyte and macrophage lineages and contrast them with earlier data gathered by the analysis of SHIP null mice.

Author-supplied keywords

  • Conditional knockout
  • Lymphocytes
  • Macrophages
  • SHIP
  • T-bet

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Wai Hang Leung

  • Tatyana Tarasenko

  • Silvia Bolland

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free