Discontinuation of anticoagulant treatment: from clinical trials to medication persistence

  • Komócsi A
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Abstract

BACKGROUND: The new generation, non-vitamin K antagonist oral anticoagulants are used in an increasing frequency, partially replacing the vitamin K antagonists in several fields of anticoagulation. Efficacy of the preventive oral anticoagulant regime, however, may be compromised by patient non-compliance. METHODS: The authors analyzed treatment discontinuation frequencies in phase 3 trials of anticoagulant treatment in non-valvular atrial fibrillation in a frequentist random effect metaanalysis and in Bayesian multiple treatment network comparison. RESULTS: Frequency of discontinuations are heterogeneous and highly inconsistent (Chi2 test for heterogeneity p

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Authors

  • András Komócsi

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