L-myo-Inositol 1-phosphate synthase (MIPS, EC 5.5.1.4), the key enzyme in the inositol and phosphoinositide biosynthetic pathway, is present throughout evolutionarily diverse organisms and is considered an ancient protein/gene. Analysis by multiple sequence alignment, phylogenetic tree generation and comparison of newly determined crystal structures provides new insight into the origin and evolutionary relationships among the various MIPS proteins/genes. The evolution of the MIPS protein/gene among the prokaryotes seems more diverse and complex than amongst the eukaryotes. However, conservation of a 'core catalytic structure' among the MIPS proteins implies an essential function of the enzyme in cellular metabolism throughout the biological kingdom. © 2003 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
CITATION STYLE
Majumder, A. L., Chatterjee, A., Dastidar, K. G., & Majee, M. (2003, October 9). Diversification and evolution of L-myo-inositol 1-phosphate synthase. FEBS Letters. Elsevier. https://doi.org/10.1016/S0014-5793(03)00974-8
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