DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts Article DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts

  • David Roulois A
  • Loo Yau H
  • Singhania R
 et al. 
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Abstract

Graphical Abstract Highlights d 5-AZA-CdR induces formation of dsRNAs and activation of the MDA5/MAVS/IRF7 pathway d An anti-proliferative response to DNA demethylation is mediated by viral mimicry d 5-AZA-CdR-mediated targeting of CICs is mainly mediated by viral mimicry d The MDA5/MAVS/IRF7 pathway is a potentially druggable target against colorectal cancer In Brief Anti-tumor DNA-demethylating agents act by inducing transcription of endogenous dsRNAs that activate the viral recognition and interferon response pathway. This anti-viral response reduces proliferation of colorectal cancer-initiating cells. Accession Numbers GSE62086 Roulois et al., 2015, Cell 162, 961–973 August 27, 2015 ª2015 Elsevier Inc.

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Authors

  • Authors David Roulois

  • Helen Loo Yau

  • Rajat Singhania

  • Trevor J Pugh

  • Daniel D De Carvalho Correspondence

  • David Roulois

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