Standard pharmacologic closure of the patent ductus arteriosus currently involves the administration of 1 of 2 cyclooxygenase inhibitors: either indomethacin or ibuprofen. However, both of these drugs can be associated with potentially significant adverse effects. We present here the cases of 5 preterm infants (gestational age: 26-32 weeks; postnatal age: 3-35 days) with large, hemodynamically significant patent ductus arteriosus who had either failed or had contraindications to ibuprofen therapy. Each of these infants was treated with off-label oral paracetamol (15 mg/kg per dose every 6 hours). Ductal closure was achieved within 48 hours in all the treated infants. No toxicity was observed. Copyright © 2011 by the American Academy of Pediatrics.
CITATION STYLE
Hammerman, C., Bin-Nun, A., Markovitch, E., Schimmel, M. S., Kaplan, M., & Fink, D. (2011). Ductal closure with paracetamol: A surprising new approach to patent ductus arteriosus treatment. Pediatrics, 128(6). https://doi.org/10.1542/peds.2011-0359
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