The economy of brain network organization

  • Bullmore E
  • Sporns O
  • 1

    Readers

    Mendeley users who have this article in their library.
  • N/A

    Citations

    Citations of this article.

Abstract

The brain is expensive, incurring high material and metabolic costs for its size-relative to the size of the body-and many aspects of brain network organization can be mostly explained by a parsimonious drive to minimize these costs. However, brain networks or connectomes also have high topological efficiency, robustness, modularity and a 'rich club' of connector hubs. Many of these and other advantageous topological properties will probably entail a wiring-cost premium. We propose that brain organization is shaped by an economic trade-off between minimizing costs and allowing the emergence of adaptively valuable topological patterns of anatomical or functional connectivity between multiple neuronal populations. This process of negotiating, and re-negotiating, trade-offs between wiring cost and topological value continues over long (decades) and short (millisecond) timescales as brain networks evolve, grow and adapt to changing cognitive demands. An economical analysis of neuropsychiatric disorders highlights the vulnerability of the more costly elements of brain networks to pathological attack or abnormal development. © 2012 Macmillan Publishers Limited. All rights reserved.

Author-supplied keywords

  • *cost minimization analysis
  • *nerve cell network
  • Alzheimer disease
  • artificial neural network
  • body size
  • brain cortex
  • brain cortex folding
  • brain development
  • brain disease
  • brain metabolism
  • brain region
  • brain size
  • cell population
  • cognition
  • cost benefit analysis
  • cytoarchitecture
  • degenerative disease
  • disease course
  • functional magnetic resonance imaging
  • human
  • multiple sclerosis
  • nerve cell excitability
  • nerve cell plasticity
  • nerve fiber
  • nerve fiber growth
  • nonhuman
  • pathophysiology
  • priority journal
  • review
  • schizophrenia
  • signal transduction
  • theoretical model
  • trans Golgi network

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Get full text

Authors

  • E. Bullmore

  • Olaf Sporns

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free