Effect of dual blockade of renin-angiotensin system on proteinuria

  • Hasani E
  • Idrizi A
  • Barbullushi M
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Abstract

Aim: Aim of the study was the evaluation of the effect of dual blockade of the renin-angiotensin system (RAS) on proteinuria. Material and Methods: Sixty patients, included in the study, were treated with angiotensin-converting enzyme inhibitor and angiotensin receptor blocker for a period of 3 months. Results: The dual blockade of RAS resulted with decrease of proteinuria, a slight increase of serum creatinine and was not associated with a lowering of blood pressure. Conclusion: Combined therapy with ACE-I and ARB results in a more complete blockade of the RAS than monotherapy. In proteinuric nephropathies it reduces significantly baseline proteinuria.

Author-supplied keywords

  • Angiotensin receptor blocker
  • Angiotensin-converting enzyme inhibitor
  • Dual blockade
  • Proteinuria
  • Renin-angiotensin system

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Authors

  • Eqerem Hasani

  • Alma Idrizi

  • Myftar Barbullushi

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