Effects of aging on lower urinary tract and pelvic floor function in nulliparous women

  • Trowbridge E
  • Wei J
  • Fenner D
 et al. 
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OBJECTIVE: To evaluate the effects of aging, independent of parity, on pelvic organ and urethral support, urethral function, and levator function in a sample of nulliparous women. METHODS: A cohort of 82 nulliparous women, aged 21-70 years, were recruited from the community through advertisements. Subjects underwent pelvic examination using pelvic organ prolapse quantification, urethral angles by cotton-tipped swab, and multichannel urodynamics and uroflow. Vaginal closure force was quantified using an instrumented vaginal speculum. Subjects were grouped into five age categories and analyses performed using t tests, Fisher exact tests, Kruskal-Wallace, and Pearson correlation coefficients. Multiple linear regression modeling was performed to adjust for factors that might confound the results of our primary outcomes. RESULTS: Increasing age was associated with decreasing maximal urethral closure pressure (r=-0.758, P

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  • E.R. Trowbridge

  • J.T. Wei

  • D.E. Fenner

  • J.A. Ashton-Miller

  • J.O.L. DeLancey

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