Effects of anti-diabetic drugs on bone metabolism

  • Mabilleau G
  • Chappard D
  • Flatt P
 et al. 
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Abstract

An increased fracture risk is observed in Type 1 and Type 2 diabetic patients. Although diabetes-related complications are important in the etiology of bone fracture in diabetes, the effect of anti-diabetic medications should not be neglected. Indeed, many drugs used commonly to treat diabetes can interfere with bone physiology, resulting in a positive or negative impact on skeletal health. The aim of the present review is to summarize the current evidence on the effects of anti-diabetic drugs on bone.

Author-supplied keywords

  • Bone fracture
  • DPP-4
  • GIP
  • GLP-1
  • SGLT-2 inhibitor
  • diabetes
  • metformin
  • sulfonylurea
  • thiazolidinediones

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