Effects of parental anxiety disorders in children at high risk for panic disorder: A controlled study

  • Petty C
  • Faraone S
 et al. 
  • 1


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


Background: To examine the association between anxiety disorders in parents and offspring in a sample of children at risk for panic disorder. We hypothesized that individual anxiety disorders will breed true in offspring. Methods: Comparisons were made between offspring of parents with PD + MD (N = 136), PD (N = 27), MD (N = 27), and Controls (N = 103). All subjects were assessed with structured diagnostic interviews. Individual anxiety disorders in the offspring were used as dependent variables in logistic regression models where parental PD status, parental MD, and the same parental anxiety diagnosis were used as independent binary variables. Results: Social phobia and separation anxiety disorder in the offspring were accounted for by the same disorders in the parent, whereas agoraphobia and OCD in the offspring were accounted for by parental panic disorder. Conclusions: These findings suggest that differing risk factors underlie the expression of individual anxiety disorders in children at risk for panic disorder. © 2006 Elsevier B.V. All rights reserved.

Author-supplied keywords

  • *agoraphobia
  • *genetic risk
  • *panic
  • *parental behavior
  • *separation anxiety
  • *social phobia
  • Adolescent
  • Adult
  • Agoraphobia/diagnosis/genetics/psychology
  • Anxiety
  • Anxiety Disorders/epidemiology/*genetics/psycholog
  • Child
  • Child of Impaired Parents/*psychology/statistics &
  • Children
  • Comorbidity
  • Cross-Sectional Studies
  • Depressive Disorder
  • Family
  • Female
  • Follow-Up Studies
  • Humans
  • Major/epidemiology/genetics/p
  • Male
  • Panic Disorder/epidemiology/*genetics/psychology
  • Panic disorder
  • Personality Assessment
  • Phobic Disorders/diagnosis/genetics/psychology
  • Preschool
  • Risk
  • Separation/epidemiology/genetics/psycholo
  • Statistics
  • Statistics as Topic
  • adolescent
  • adult
  • anxiety disorder
  • article
  • child
  • controlled study
  • family
  • female
  • high risk population
  • human
  • logistic regression analysis
  • major clinical study
  • male
  • priority journal
  • progeny
  • psychiatric diagnosis
  • psychologic test
  • statistical model
  • structured interview

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Joseph BIEDERMAN

  • Carter Petty

  • S.V. Stephen V. Faraone

  • Aude Henin

  • Dina Hirshfeld-Becker

  • Mark H. M.H. Mark H. Pollack

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free