Electrophysiological localization of the subthalamic nucleus in parkinsonian patients

  • Pralong E
  • Ghika J
  • Temperli P
 et al. 
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Abstract

Deep brain stimulation of the subthalamic nucleus (STN) is becoming the procedure of choice to reduce symptoms of Parkinson's disease such as rigidity, akinesia and tremor. We present here a series of electrophysiological recordings performed in 34 patients along a standardized electrode trajectory. Neuronal activity along the trajectory consists of a first heterogeneous population of thalamic cells with a mean frequency of 24.8±1.4 Hz followed by a silent zone and a second population of STN neurones with a significantly higher spiking frequency (P

Author-supplied keywords

  • Electrophysiology
  • Extracellular recordings
  • Human
  • Parkinson
  • Subthalamic nucleus

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Authors

  • Etienne Pralong

  • Joseph Ghika

  • Philippe Temperli

  • Claudio Pollo

  • Francois Vingerhoets

  • Jean Guy Villemure

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