Deep brain stimulation of the subthalamic nucleus (STN) is becoming the procedure of choice to reduce symptoms of Parkinson's disease such as rigidity, akinesia and tremor. We present here a series of electrophysiological recordings performed in 34 patients along a standardized electrode trajectory. Neuronal activity along the trajectory consists of a first heterogeneous population of thalamic cells with a mean frequency of 24.8±1.4 Hz followed by a silent zone and a second population of STN neurones with a significantly higher spiking frequency (P<0.001) of 42.3±1.8 Hz. This study confirms previous findings and suggests that rapid measurement of neuronal spiking frequency and burst index is sufficient to determine precisely the vertical position of the STN. © 2002 Elsevier Science Ireland Ltd. All rights reserved.
CITATION STYLE
Pralong, E., Ghika, J., Temperli, P., Pollo, C., Vingerhoets, F., & Villemure, J. G. (2002). Electrophysiological localization of the subthalamic nucleus in parkinsonian patients. Neuroscience Letters, 325(2), 144–146. https://doi.org/10.1016/S0304-3940(02)00265-3
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