An electrospray method is developed for preparation of beclomethasonedipropionate- and salbutamol-sulfate-loaded biodegradable poly(L-lactic acid) nanoparticles. Different set-up parameters for electrospraying are examined on particle size, and preparation conditions are optimized for producing spherical-drug-loaded nanoscale particles by controllable processing parameters. Polylactide (PLA)-drug nanoparticles with average diameters of around 200nm are achieved in a stable cone-jet mode with a flow rate of 4 μL min-1, polymer concentration of 1%, and ammonium hydroxide content of 0.05%. Morphology and size of the drug-polymer nanoparticles are analyzed by scanning electron microscopy and transmission electron microscopy. Changes in the crystallinity of the PLA polymer and the model drugs are detected by X-ray powder diffraction, and the absence of molecular interactions are confirmed by thermal analyses. The results indicate clearly that electrospraying is a potential method for producing polymeric nanoparticles and for encapsulating both hydrophilic and hydrophobic drugs efficiently into the nanoparticles. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
CITATION STYLE
Valo, H., Peltonen, L., Vehviläinen, S., Karjalainen, M., Kostiainen, R., Laaksonen, T., & Hirvonen, J. (2009). Electrospray encapsulation of hydrophilic and hydrophobic drugs in poly(L-lactic acid) nanoparticles. Small, 5(15), 1791–1798. https://doi.org/10.1002/smll.200801907
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