Engineering of Brome mosaic virus for biomedical applications

  • Yildiz I
  • Tsvetkova I
  • Wen A
 et al. 
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Abstract

Viral nanoparticles (VNPs) are becoming versatile tools in platform
technology development. Their well-defined structures as well as their
programmability through chemical and genetic modification allow VNPs to
be engineered for potential imaging and therapeutic applications. In
this article, we report the application of a variety of bioconjugation
chemistries to the plant VNP Brome mosaic virus (BMV). Functional BMV
nanoparticles displaying multiple copies of fluorescent dyes, PEG
molecules, chemotherapeutic drug moieties, targeting proteins and cell
penetrating peptides were formulated. This opens the door for the
application of BMV in nanomedicine.

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Authors

  • Ibrahim Yildiz

  • Irina Tsvetkova

  • Amy M. Wen

  • Sourabh Shukla

  • M. Hema Masarapu

  • Bogdan Dragnea

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