Enhanced delivery of baicalein using cinnamaldehyde cross-linked chitosan nanoparticle inducing apoptosis

  • Nipun Babu V
  • Kannan S
  • 27

    Readers

    Mendeley users who have this article in their library.
  • 25

    Citations

    Citations of this article.

Abstract

The chitosan (CS) nanoparticles, baicalein loaded chitosan nanoparticles were prepared by crosslinking method in a W/O emulsion system, using cinnamaldehyde as crosslinking agent. The FT-IR result showed the binding of anticancer compound baicalein to the nanoparticles. The TEM analysis revealed that the particles are spherical in nature. Zeta potential revealed negative charge of the particles. Ultraviolet spectrum analysis described that higher loading efficiency and encapsulation efficiency as 9.1% and 97.2%, respectively. In vitro baicalein release profile demonstrated the delivery of baicalein from the CS nanoparticles is a two stage process. RT-PCR and cell culture was carried out accordingly. © 2012 Elsevier B.V.

Author-supplied keywords

  • Apoptosis
  • Baicalein
  • Chitosan
  • Cinnamaldehyde

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free