Enhanced, simplified glucose sensors: Long-term clinical application of wearable artificial endocrine pancreas

  • Shichiri M
  • Sakakida M
  • Nishida K
 et al. 
  • 28

    Readers

    Mendeley users who have this article in their library.
  • 62

    Citations

    Citations of this article.

Abstract

At present, 2 major problems should be solved before long-term application of the wearable artificial endocrine pancreas, the development of a reliable and stable glucose monitoring system and the development of a subcutaneous insulin infusion algorithm. With either a miniaturized extracorporeal glucose monitoring system based on microdialysis sampling method or a ferrocene-mediated needle-type glucose sensor covered with highly biocompatible membrane, poly(2-methacryloyloxyethyl phosphorylcholine-co-n-butyl methacrylate) (poly[MPC-co-BMA]) membrane, subcutaneous glucose concentrations could be monitored for 7 days without any in vivo calibrations, followed by 14 days with one point calibration. Considering the management and safety of the insulin delivery route, subcutaneous insulin infusion is obligatory. With the subcutaneous insulin infusion algorithm using a short acting insulin analogue (Insulin Lispro), near physiological glycemic control could be established in diabetic patients without showing any delayed hyperinsulinemia or hypoglycemia. The wearable artificial endocrine pancreas is now recognized as an excellent therapeutic tool for regulating blood glucose excursions physiologically in ambulatory diabetic patients on a long-term basis.

Author-supplied keywords

  • Ferrocene- mediated needle-type glucose sensor
  • Miniaturized extracorporeal glucose monitoring system based on microdialysis sampling method
  • Poly(2-methacryloyloxyethyl phosphorylcholine-co-n-butyl methacrylate) membrane
  • Short acting insulin analogue
  • Subcutaneous insulin infusion algorithm
  • Wearable artificial endocrine pancreas

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Motoaki Shichiri

  • Michiharu Sakakida

  • Kenro Nishida

  • Seiya Shimoda

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free