ENRICHD and SADHART: Implications for future biobehavioral intervention efforts.

  • Sheps D
  • Freedland K
  • Golden R
 et al. 
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Briefly discusses the results of the Enhancing Recovery in Coronary Heart Disease (ENRICHD) trial and the Sertraline Antidepressant Heart Attack Trial (SADHART) which have produced disappointment and concern. It is noted that the ENRICHD and SADHART depression outcomes fell short of expectation and the ENRICHD intervention failed to prolong reinfarction-free survival. The authors argue that researchers should not abandon this form of investigation but should instead set their sights on the appropriate design of future studies. (PsycINFO Database Record (c) 2012 APA, all rights reserved)

Author-supplied keywords

  • Coronary heart disease
  • ENRICHD trial
  • Experimentation
  • Heart Disorders
  • Heart attack
  • Recovery (Disorders)
  • biobehavioral intervention
  • depression
  • drug therapy
  • early intervention
  • major depression
  • recovery
  • sertraline

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  • SCOPUS: 2-s2.0-0037247937
  • SGR: 0037247937
  • ISSN: 0033-3174
  • ISBN: 0033-3174
  • PUI: 36143191
  • PMID: 12554810


  • David S Sheps

  • Kenneth E Freedland

  • Robert N Golden

  • Robert P McMahon

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