Three equivocal amino acid sequences were synthesized that are predicted to be α-helical from amino acid preference but are found to be primarily β-strand from x-ray diffraction of their respective proteins. In some solvent systems we recover the α-helical structure predicted by amino acid preference, whereas in other systems we mimic the interior of the protein and produce a β-strand. These results are experimental proof that the environment is important in determining the secondary structure formed by an amino acid sequence; therefore schemes that predict secondary structure from amino acid sequence alone can never be totally successful.
CITATION STYLE
Zhong, L., & Johnson, W. C. (1992). Environment affects amino acid preference for secondary structure. Proceedings of the National Academy of Sciences of the United States of America, 89(10), 4462–4465. https://doi.org/10.1073/pnas.89.10.4462
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