Epstein-Barr virus as a possible etiologic agent in primary central nervous system lymphoma in immunocompetent individuals

  • A. T
  • S. C
  • M. S
 et al. 
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Abstract

BACKGROUND: Primary central nervous system lymphoma (PCNSL) occurs in both immunocompetent and immunosuppressed individuals. The role of Epstein-Barr virus (EBV) has been implicated in immunosuppressed individuals but its role is not established in immunocompetent individuals., AIMS: To study the possible role of EBV in PCNSL in immunocompetent individuals., SETTING AND DESIGN: Retrospective study., MATERIALS AND METHODS: Thirty patients with PCNSL were studied immunohistochemically with antibodies to CD45, CD20, CD3 and EBV latent membrane protein-1 (EBV LMP-1). In situ hybridization was done in 19 patients where enough tissue was available using a specific oligonucleotide probe for EBV-Early RNA (EBER)., RESULTS: All the patients were immunocompetent and mean age was 41.6 years. Histologically they were diffuse large cell lymphoma: 25 (83.3%) were B cell, 1(3.3%) was T cell and 4 (13.3%) were unclassified. EBV LMP-1 showed variable membrane and cytoplasmic positivity in 24 (80%) patients. In situ hybridization for EBER was negative in all the 19 patients studied., CONCLUSION: In this region of the world probably EBV has no etiologic role in PCNSL in immunocompetent individuals.

Author-supplied keywords

  • *Central Nervous System Neoplasms/et [Etiology]
  • *Central Nervous System Neoplasms/vi [Virology]
  • *Epstein Barr virus
  • *Epstein-Barr Virus Infections/co [Complications]
  • *Epstein-Barr Virus Infections/vi [Virology]
  • *Herpesvirus 4
  • *Lymphoma/et [Etiology]
  • *Lymphoma/vi [Virology]
  • *primary central nervous system lymphoma
  • Adolescent
  • Adult
  • Aged
  • B cell lymphoma
  • CD20 antigen/ec [Endogenous Compound]
  • CD3 antigen/ec [Endogenous Compound]
  • CD45 antigen/ec [Endogenous Compound]
  • Central Nervous System Neoplasms/pa [Pathology]
  • DNA Primers
  • Epstein-Barr Virus Infections/pa [Pathology]
  • Female
  • Human
  • Humans
  • Immunocompetence
  • Immunohistochemistry
  • In Situ Hybridization
  • Lymphoma/pa [Pathology]
  • Male
  • Middle Aged
  • T cell lymphoma
  • Young Adult
  • adolescent
  • adult
  • aged
  • article
  • clinical article
  • controlled study
  • female
  • histopathology
  • human
  • human tissue
  • immunocompetence
  • immunohistochemistry
  • in situ hybridization
  • large cell lymphoma
  • latent membrane protein 1
  • leukocyte antibody
  • male
  • oligonucleotide probe
  • virus RNA

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Authors

  • Tandon A.

  • Challa S.

  • Shanmugam M.

  • Gopalan S.

  • Paul R.T.

  • Ashwani Tandon

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