Journal article

Evaluation of basket and paddle dissolution methods using different performance standards

Prasad V, Shah V, Hunt J, Purich E, Knight P, Cabana B ...see all

Journal of Pharmaceutical Sciences, vol. 72, issue 1 (1983) pp. 42-44

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Abstract

Dissolution studies using both basket and paddle methods were carried out to evaluate two prednisone standards. Results of the experiments showed that the USP prednisone calibrator is sensitive to perturbations by the basket method but not to perturbations by the paddle method. However, the National Center for Drug Analysis (NCDA) prednisone performance standard is sensitive to perturbations by the paddle method but not to perturbations by the basket method. These results suggest that no single standard can predict the suitability of the dissolution equipment by the basket and paddle methods.

Author-supplied keywords

  • Basket dissolution method—prednisone, evaluation using different performance standards
  • Dissolution—evaluation of basket and paddle methods using different performance standards, prednisone
  • Paddle dissolution method—prednisone evaluation using different performance standards
  • Prednisone—evaluation of basket and paddle dissolution methods using different performance standards

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Authors

  • Vadlamani K. Prasad

  • Vinod P. Shah

  • John Hunt

  • Edward Purich

  • Patrick Knight

  • Bernard E. Cabana

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