Evidence for balancing selection at the DAB locus in the axolotl, Ambystoma mexicanum

  • Richman A
  • Herrera G
  • Reynoso V
 et al. 
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The axolotl (Ambystoma mexicanum) has been characterized as immunodeficient, and the absence of major histocompatibility complex (MHC) class II polymorphism has been cited as a possible explanation. Here we present evidence for considerable allelic polymorphism at the MHC class II DAB locus for a sample of wild-caught axolotls. Evidence that these sequences are the product of balancing selection for disease resistance is discussed.

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  • Luis ZambranoNational Autonomous University of Mexico Institute of Biology

  • A. D. Richman

  • G. Herrera

  • V. H. Reynoso

  • G. Méndez

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