Expanded roles of the Fanconi anemia pathway in preserving genomic stability

  • Kee Y
  • D'Andrea A
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Studying rare human genetic diseases often leads to a better understanding of normal cellular functions. Fanconi anemia (FA), for example, has elucidated a novel DNA repair mechanism required for maintaining genomic stability and preventing cancer. The FA pathway, an essential tumor-suppressive pathway, is required for protecting the human genome from a specific type of DNA damage; namely, DNA interstrand cross-links (ICLs). In this review, we discuss the recent progress in the study of the FA pathway, such as the identification of new FANCM-binding partners and the identification of RAD51C and FAN1 (Fanconi-associated nuclease 1) as new FA pathway-related proteins. We also focus on the role of the FA pathway as a potential regulator of DNA repair choices in response to double-strand breaks, and its novel functions during the mitotic phase of the cell cycle.

Author-supplied keywords

  • DNA repair
  • Fanconi anemia
  • Homologous recombination (HR)
  • Interstrand cross-link (ICL)
  • Mitosis
  • Nonhomologous end-joining (NHEJ)

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  • Younghoon Kee

  • Alan D. D'Andrea

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