A general method for the facile and versatile decoration of peptides is proposed exploiting furan based cycloaddition and electrophilic aromatic substitution reactions. Given the commercial availability of furylalanine derivatives for peptide synthesis, the current work significantly enlarges the toolbox of available methodologies for site specific labeling and conjugation of peptide probes. © 2013 The Royal Society of Chemistry.
CITATION STYLE
Hoogewijs, K., Buyst, D., Winne, J. M., Martins, J. C., & Madder, A. (2013). Exploiting furan’s versatile reactivity in reversible and irreversible orthogonal peptide labeling. Chemical Communications, 49(28), 2927–2929. https://doi.org/10.1039/c3cc40588e
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